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Iron And Cholesterol And Cancer

From: teamtanner@hotmail.com (ironjustice)


High iron and cholesterol equals high cancer risk: Study
Submitted 2 days 4 hrs ago

High blood levels of iron coupled with high levels of
very low density (VLDL) lipoprotein cholesterol appear
to interact to increase the risk of cancer,
"Iron and lipids combine to create oxidative stress, and
oxidative stress has a role in the development of cancer,"
Dr. Arch G. Mainous III, of the Medical University of South
Carolina, Charleston, and colleague write in the American
Journal of Epidemiology.
The researchers examined the risk of cancer among 3278
subjects in the Framingham Offspring Study who had elevated
iron and lipid levels.
The participants were at least 30 years of age when they
enrolled in the study between 1979 and 1982, at which point
their blood levels of iron and HDL, LDL, and VLDL cholesterol
were measured.
They were followed up for development of cancer until 1996
to 1997.
The team reports that elevated iron increased the likelihood
of developing cancer by 66 percent, and high VLDL cholesterol
increased the risk by 54 percent.
Combining elevated iron with elevated VLDL increased the risk
of cancer by 168 percent.
High iron plus low HDL ("good") cholesterol also increased
the risk to a similar degree.
"These findings support the hypothesis that iron-mediated
oxidation of cholesterol increases oxidative stress, which can
lead to cancer formation," Mainous and colleagues conclude.
Assuming the finding is confirmed by others, they say, it
suggests a need "to reduce iron and/or lipid levels in persons
with dual elevations in these substance as a strategy to
decrease cancer risk."


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