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Addiction Is a Brain Disease - Leshner

From: imbibe@mindspring.com ((David P.))




ALAN I. LESHNER

Addiction Is a Brain Disease

Greater progress will be made against drug abuse when our
strategies reflect the full complexities of the latest
scientific understanding.  The United States is stuck in its
drug abuse metaphors and in polarized arguments about them.
Everyone has an opinion. One side insists we must control
supply, the other that we must reduce demand. People see
addiction as either a disease or as a failure of will. None
of this bumpersticker analysis moves us forward. The truth
is that we will make progress in dealing with drug issues
only when our national discourse and our strategies are as
complex & comprehensive as the problem itself.  A core concept
that has been evolving with scientific advances over the past
decade is that drug addiction is a brain disease that develops
over time as a result of the initially voluntary behavior of
using drugs. The consequence is virtually uncontrollable
compulsive drug craving, seeking, & use that interferes with,
if not destroys, an individual's functioning in the family &
in society. This medical condition demands formal treatment.
We now know in great detail the brain mechanisms through which
drugs acutely modify mood, memory, perception, and emotional
states. Using drugs repeatedly over time changes brain structure
& function in fundamental & long-lasting ways that can persist
long after the individual stops using them. Addiction comes
about through an array of neuroadaptive changes and the laying
down and strengthening of new memory connections in various
circuits in the brain. We do not yet know all the relevant
mechanisms, but the evidence suggests that those long-lasting
brain changes are responsible for the distortions of cognitive
& emotional functioning that characterize addicts, particularly
including the compulsion to use drugs that is the essence of
addiction. It is as if drugs have highjacked the brain's natural
motivational control circuits, resulting in drug use becoming
the sole, or at least the top, motivational priority for the
individual. Thus, the majority of the biomedical community now
considers addiction, in its essence, to be a brain disease: a
condition caused by persistent changes in brain structure and
function.

This brain-based view of addiction has generated substantial
controversy, particularly among people who seem able to think
only in polarized ways. Many people erroneously still believe
that biological and behavioral explanations are alternative or
competing ways to understand phenomena, when in fact they are
complementary & integratable. Modern science has taught that it's
much too simplistic to set biology in opposition to behavior or
to pit willpower against brain chemistry. Addiction involves
inseparable biological and behavioral components. It is the
quintessential biobehavioral disorder.  Many people also
erroneously still believe that drug addiction is simply a
failure of will or of strength of character. Research contra-
dicts that position. However, the recognition that addiction
is a brain disease does not mean that the addict is simply a
hapless victim. Addiction begins with the voluntary behavior
of using drugs, and addicts must participate in and take some
significant responsibility for their recovery. Thus, having this
brain disease does not absolve the addict of responsibility for
his or her behavior, but it does explain why an addict cannot
simply stop using drugs by sheer force of will alone. It also
dictates a much more sophisticated approach to dealing with
the array of problems surrounding drug abuse and addiction in
our society.

The essence of addiction

The entire concept of addiction has suffered greatly from
imprecision and misconception. In fact, if it were possible,
it would be best to start all over with some new, more neutral
term. The confusion comes about in part because of a now archaic
distinction between whether specific drugs are "physically" or
"psychologically" addicting. The distinction historically
revolved around whether or not dramatic physical withdrawal
symptoms occur when an individual stops taking a drug; what we
in the field now call "physical dependence." However, 20 years
of scientific research has taught that focusing on this physical
versus psychological distinction is off the mark & a distraction
from the real issues. From both clinical & policy perspectives,
it actually does not matter very much what physical withdrawal
symptoms occur. Physical dependence is not that important,
because even the dramatic withdrawal symptoms of heroin and
alcohol addiction can now be easily managed with appropriate
medications. Even more important, many of the most dangerous &
addicting drugs, including methamphetamine and crack cocaine,
do not produce very severe physical dependence symptoms upon
withdrawal.  What really matters most is whether or not a drug
causes what we now know to be the essence of addiction: uncon-
trollable, compulsive drug craving, seeking, and use, even in
the face of negative health and social consequences. This is
the crux of how the Inst. of Medicine, the American Psychiatric
Assn, & the American Medical Assn define addiction & how we all
should use the term. It is really only this compulsive quality
of addiction that matters in the long run to the addict and to
his or her family and that should matter to society as a whole.
Compulsive craving that overwhelms all other motivations is the
root cause of the massive health and social problems associated
with drug addiction. In updating our national discourse on drug
abuse, we should keep in mind this simple definition: Addiction
is a brain disease expressed in the form of compulsive behavior.
Both developing & recovering from it depend on biology, behavior,
and social context.

It is also important to correct the common misimpression that
drug use, abuse, & addiction are points on a Singles Chat">single continuum
along which one slides back and forth over time, moving from
user to addict, then back to occasional user, then back to
addict. Clinical observation and more formal research studies
support the view that, once addicted, the individual has moved
into a different state of being. It is as if a threshold has
been crossed. Very few people appear able to successfully return
to occasional use after having been truly addicted. Unfortunately,
we do not yet have a clear biological or behavioral marker of
that transition from voluntary drug use to addiction. However,
a body of scientific evidence is rapidly developing that points
to an array of cellular and molecular changes in specific brain
circuits. Moreover, many of these brain changes are common to
all chemical addictions, and some also are typical of other
compulsive behaviors such as pathological overeating.  Addiction
should be understood as a chronic recurring illness. Although
some addicts do gain full control over their drug use after a
single treatment episode, many have relapses. Repeated treatments
become necessary to increase the intervals between and diminish
the intensity of relapses, until the individual achieves abstinence.
The complexity of this brain disease is not atypical, because
virtually no brain diseases are simply biological in nature &
expression. All, including stroke, Alzheimer's disease, schizo-
phrenia, and clinical depression, include some behavioral and
social aspects. What may make addiction seem unique among brain
diseases, however, is that it does begin w/ a clearly voluntary
behavior--the initial decision to use drugs. Moreover, not
everyone who ever uses drugs goes on to become addicted.
Individuals differ substantially in how easily & quickly they
become addicted & in their preferences for particular substances.
Consistent with the biobehavioral nature of addiction, these
individual differences result from a combo of environmental &
biological, particularly genetic, factors. In fact, estimates
are that between 50 & 70 % of the variability in susceptibility
to becoming addicted can be accounted for by genetic factors.
Although genetic characteristics may predispose individuals to
be more or less susceptible to becoming addicted, genes do not
doom one to become an addict.

Over time the addict loses substantial control over his or her
initially voluntary behavior, and it becomes compulsive. For
many people these behaviors are truly uncontrollable, just like
the behavioral expression of any other brain disease. Schizo-
phrenics cannot control their hallucinations and delusions.
Parkinson's patients cannot control their trembling. Clinically
depressed patients cannot voluntarily control their moods. Thus,
once one is addicted, the characteristics of the illness--and
the treatment approaches--aren't that different from most other
brain diseases. No matter how one develops an illness, once one
has it, one is in the diseased state and needs treatment.
Moreover, voluntary behavior patterns are, of course, involved
in the etiology and progression of many other illnesses, albeit
not all brain diseases. Examples abound, including hypertension,
arteriosclerosis and other cardiovascular diseases, diabetes, &
forms of cancer in which the onset is heavily influenced by the
individual's eating, exercise, smoking, and other behaviors.
Addictive behaviors do have special characteristics related to
the social contexts in which they originate. All of the environ-
mental cues surrounding initial drug use and development of the
addiction actually become "conditioned" to that drug use & are
thus critical to the development and expression of addiction.
Environmental cues are paired in time with an individual's
initial drug use experiences &, through classical conditioning,
take on conditioned stimulus properties. When those cues are
present at a later time, they elicit anticipation of a drug
experience & thus generate tremendous drug craving. Cue-induced
craving is one of the most frequent causes of drug use relapses,
even after long periods of abstinence, independently of whether
drugs are available.

The salience of environmental or contextual cues helps explain
why reentry to one's community can be so difficult for addicts
leaving the controlled environments of treatment or correctional
settings & why aftercare is so essential to successful recovery.
The Pictures of People">person who became addicted in the home environment is
constantly exposed to the cues conditioned to his or her initial
drug use, such as the neighborhood where he or she hung out,
drug-using buddies, or the lamppost where he or she bought drugs.
Simple exposure to those cues automatically triggers craving &
can lead rapidly to relapses. This is one reason why someone who
apparently overcame drug cravings while in prison or residential
treatment could quickly revert to drug use upon returning home.
In fact, one of the major goals of drug addiction treatment is
to teach addicts how to deal w/ the cravings caused by inevitable
exposure to these conditioned cues.

Implications

Understanding addiction as a brain disease has broad/significant
implications for the public perception of addicts & families,
for addiction treatment practice, & for some aspects of public
policy. On the other hand, this biomedical view of addiction
does not speak directly to & is unlikely to bear significantly
on many other issues, including strategies for controlling the

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supply of drugs and whether initial drug use should be legal or

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not. Moreover, the brain disease model of addiction does not

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address the question of whether specific drugs of abuse can

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also be potential medicines. Examples abound of drugs that can

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be both highly addicting and extremely effective medicines.

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The best-known example is the appropriate use of morphine as a

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treatment for pain. Nevertheless, a number of practical lessons

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can be drawn from the scientific understanding of addiction.

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It is no wonder addicts cannot simply quit on their own. They

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have an illness that requires biomedical treatment. People

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often assume that because addiction begins with a voluntary

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behavior and is expressed in the form of excess behavior, people

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should just be able to quit by force of will alone. However, it

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is essential to understand when dealing with addicts that we are

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dealing with individuals whose brains have been altered by drug

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use. They need drug addiction treatment. We know that, contrary

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to common belief, very few addicts actually do just stop on their

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own. Observing that there are very few heroin addicts in their

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50 or 60s, people frequently ask what happened to those who were

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heroin addicts 30 years ago, assuming that they must have quit

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on their own. However, longitudinal studies find that only a very

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small fraction actually quit on their own. The rest have either

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been successfully treated, are currently in maintenance treatment,

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or (for about half) are dead. Consider the example of smoking

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cigarettes: Various studies have found that between 3 & 7 % of

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people who try to quit on their own each year actually succeed.

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Science has at last convinced the public that depression is not

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just a lot of sadness; that depressed individuals are in a

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different brain state and thus require treatment to get their

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symptoms under control. The same is true for schizo patients.

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It is time to recognize that this is also the case for addicts.

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The role of personal responsibility is undiminished but clarified.

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Does having a brain disease mean that people who are addicted no

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longer have any responsibility for their behavior or that they

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are simply victims of their own genetics and brain chemistry? Of

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course not. Addiction begins with the voluntary behavior of drug

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use, & although genetic characteristics may predispose individuals

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to be more or less susceptible to becoming addicted, genes do not

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doom one to become an addict. This is one major reason why efforts

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to prevent drug use are so vital to any comprehensive strategy to

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deal with the nation's drug problems. Initial drug use is a

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voluntary, and therefore preventable, behavior.  Moreover, as

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with any illness, behavior becomes a critical part of recovery.

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At a minimum, one must comply with the treatment regimen, which

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is harder than it sounds. Treatment compliance is the biggest

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cause of relapses for all chronic illnesses, including asthma/

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diabetes/hypertension, & addiction. Moreover, compliance rates

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are no worse for addiction than for these other illnesses,

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ranging from 30 to 50 percent. Thus, for drug addiction as well

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as for other chronic diseases, the individual's motivation and

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behavior are clearly important parts of success in treatment and

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recovery.

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Implications for treatment approaches & treatment expectations.

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Maintaining this comprehensive biobehavioral understanding of

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addiction also speaks to what needs to be provided in drug

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treatment programs. Again, we must be careful not to pit biology

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against behavior. The National Institute on Drug Abuse's recently

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published Principles of Effective Drug Addiction Treatment

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provides a detailed discussion of how we must treat all aspects

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of the individual, not just the biological component or the

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behavioral component. As with other brain diseases such as

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schizophrenia and depression, the data show that the best drug

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addiction treatment approaches attend to the entire individual,

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combining the use of medications, behavioral therapies, and

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attention to necessary social services and rehabilitation.

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These might include such services as family therapy to enable

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the patient to return to successful family life, mental health

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services, education and vocational training, & housing services.

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That does not mean, of course, that all individuals need all

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components of treatment and all rehabilitation services. Another

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principle of effective addiction treatment is that the array of

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services included in an individual's treatment plan must be

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matched to his or her particular set of needs. Moreover, since

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those needs will surely change over the course of recovery, the

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array of services provided will need to be continually reassessed

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and adjusted.

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What to do with addicted criminal offenders.

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One obvious conclusion is that we need to stop simplistically

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viewing criminal justice and health approaches as incompatible

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opposites. The practical reality is that crime & drug addiction

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often occur in tandem: Between 50 and 70 percent of arrestees

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are addicted to illegal drugs. Few citizens would be willing to

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relinquish criminal justice system control over individuals,

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whether they are addicted or not, who have committed crimes

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against others. Moreover, extensive real-life experience shows

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that if we simply incarcerate addicted offenders without treating

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them, their return to both drug use and criminality is virtually

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guaranteed.  A growing body of scientific evidence points to a

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much more rational and effective blended public health/public

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safety approach to dealing with the addicted offender. Simply

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summarized, the data show that if addicted offenders are provided

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with well-structured drug treatment while under criminal justice

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control, their recidivism rates can be reduced by 50 to 60 % for

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subsequent drug use & by more than 40 % for further criminal

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behavior. Moreover, entry into drug treatment need not be

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completely voluntary in order for it to work. In fact, studies

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suggest that increased pressure to stay in treatment--whether

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from the legal system or from family members or employers--

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actually increases the amount of time patients remain in treat-

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ment and improves their treatment outcomes.

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Findings such as these are the underpinning of a very important

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trend in drug control strategies now being implemented in the

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United States & many foreign countries. For example, some 40 %

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of prisons and jails in this country now claim to provide some

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form of drug treatment to their addicted inmates, although we do

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not know the quality of the treatment provided. Diversion to

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drug treatment programs as an alternative to incarceration is

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gaining popularity across the US. The widely applauded growth

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in drug treatment courts over the past five years--to more than

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400--is another successful example of the blending of public

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health and public safety approaches. These drug courts use a

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combination of criminal justice sanctions & drug use monitoring

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and treatment tools to manage addicted offenders.

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Updating the discussion

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Understanding drug abuse and addiction in all their complexity

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demands that we rise above simplistic polarized thinking about

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drug issues. Addiction is both a public health and a public

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safety issue, not one or the other. We must deal with both the

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supply and the demand issues with equal vigor. Drug abuse and

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addiction are about both biology and behavior. One can have a

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disease and not be a hapless victim of it.  We also need to

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abandon our attraction to simplistic metaphors that only

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distract us from developing appropriate strategies. I, for one,

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will be in some ways sorry to see the War on Drugs metaphor go

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away, but go away it must. At some level, the notion of waging

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war is as appropriate for the illness of addiction as it is for

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our War on Cancer, which simply means bringing all forces to

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bear on the problem in a focused and energized way. But, sadly,

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this concept has been badly distorted and misused over time, &

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the War on Drugs never became what it should have been: the War

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on Drug Abuse and Addiction. Moreover, worrying about whether

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we are winning or losing this war has deteriorated to using

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simplistic and inappropriate measures such as counting drug

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addicts. In the end, it has only fueled discord. The War on

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Drugs metaphor has done nothing to advance the real conceptual

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challenges that need to be worked through.

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I hope, though, that we'll all resist the temptation to replace

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it with another catchy phrase that inevitably will devolve into

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a search for quick or easy-seeming solutions to drug problems.

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We do not rely on simple metaphors or strategies to deal with

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our other major national problems such as education, health

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care, or national security. We are, after all, trying to solve

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truly monumental, multidimensional problems on a national or

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even int'l scale. To devalue them to the level of slogans does

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our public an injustice and dooms us to failure.  Understanding

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the health aspects of addiction is in no way incompatible with

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the need to control the supply of drugs. In fact, a public

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health approach to stemming an epidemic or spread of a disease

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always focuses comprehensively on the agent, the vector, and

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the host. In the case of drugs of abuse, the agent is the drug,

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the host is the abuser or addict, & the vector for transmitting

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the illness is clearly the drug suppliers and dealers that keep

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the agent flowing so readily. Prevention and treatment are the

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strategies to help protect the host. But just as we must deal

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with the flies and mosquitoes that spread infectious diseases,

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we must directly address all the vectors in the drug-supply

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system.  In order to be truly effective, the blended public

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health/public safety approaches advocated here must be imple-

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mented at all levels of society--local, state, and national.

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All drug problems are ultimately local in character and impact,

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since they differ so much across geographic settings & cultural

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contexts, and the most effective solutions are implemented at

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the local level. Each community must work thru its own locally

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appropriate antidrug implementation strategies, & those strate-

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gies must be just as comprehensive and science-based as those

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instituted at the state or national level.

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The message from the now very broad & deep array of scientific

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evidence is absolutely clear. If we as a society ever hope to

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make any real progress in dealing with our drug problems, we

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are going to have to rise above moral outrage that addicts have

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"done it to themselves" & develop strategies that are as sophis-

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ticated and as complex as the problem itself. Whether addicts

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are "victims" or not, once addicted they must be seen as "brain

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disease patients."  Moreover, although our national traditions

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do argue for compassion for those who are sick, no matter how

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they contracted their illnesses, I recognize that many addicts

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have disrupted not only their own lives but those of their

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families and their broader communities, and thus do not easily

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generate compassion. However, no matter how one may feel about

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addicts and their behavioral histories, an extensive body of

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scientific evidence shows that approaching addiction as a

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treatable illness is extremely cost-effective, both financially

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& in terms of broader societal impacts such as family violence,

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crime, and other forms of social upheaval. Thus, it is clearly

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in everyone's interest to get past the hurt & indignation &

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slow the drain of drugs on society by enhancing drug use

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prevention efforts and providing treatment to all who need it.

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..

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..

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--

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Subject
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